Computational methods to identify miRNA targets
نویسندگان
چکیده
منابع مشابه
A Computational High-Throughput Method for Detecting miRNA Targets
MicroRNAs (miRNAs) have recently been discovered as an important class of non-coding RNA genes that play a major role in regulating gene expression, providing a means to control the relative amounts of mRNA transcripts and their protein products. Although much work has been done in the genomewide computational prediction of miRNA genes and their target mRNAs, an open problem is how to efficient...
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The identification of miRNAs and their target mRNAs and the construction of their regulatory networks may give new insights into biological procedures. This study proposes a computational method to discover the functional miRNA-mRNA regulatory modules (FMRMs), that is, groups of miRNAs and their target mRNAs that are believed to participate cooperatively in post-transcriptional gene regulation ...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2010
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2010.01.004